Intermediates

CAS#	Main Intermediates
	Linzagolix Choline (Yselty) CAS 935283-04-8 (Treatment of leiomyomas) and intermediates
450-93-1	4-Fluoro-2-methoxyphenol
187543-87-9	2,3-Difluoro-6-methoxybenz aldehyde
935287-59-5	5-((2,3-difluoro-6-methoxyb enzyloxy)-2-fluoro-4-methox yaniline
1581731-15-8	dimethyl4-(phenoxycarbonylamino)t hiophene-2,3-dicarboxylate
1073435-71-8	1,2-difluoro-3-((4-fluoro-2- methoxy-5-nitrophenoxy)me thyl)-4-methoxybenzene
1073435-67-2	2,3-Difluoro-6-methoxybenz yl Chloride
121071-71-4	Dimethyl 4-aminothiophene-2,3-dicar boxylate hydrochloride

	Relugolix(RELUMINA/Orgovyx) CAS 737789-87-6 (Treatment of prostate cancer and leiomyomas)
2768834-98-4	3-Thiophenecarboxylic acid,5-(4-aminophenyl) -2-[[(2,6-difluorophenyl )methyl](ethoxycarbon yl)amino]-4-[(dimethyl amino)methyl]-,ethylest er, hydrochloride (1:2)
308831-94-9	2-[[(2,6-difluorophenyl)methyl](ethoxycarbon yl)amino]-4-methyl-5-( 4-nitrophenyl)-3-Thiop henecarboxylic acid
1589503-97-8	2-[(2,6-Difluorobenzyl) ethoxycarbonylamino]- 4-((dimethylamino)met hyl)-5-(4-nitrophenyl)t hiophene-3-carboxylic acid ethyl ester
7252-84-8	3-amino-6-methoxypyri dazine
1589503-95-6	2-((2,6-difluorobenzyl)( ethoxycarbonyl)amino)-4-((dimethylamino)me thyl)-5-(4-nitrophenyl)t hiophene-3-carboxylic acid

	Elagolix Sodium (ORILISSA) CAS 832720-36-2 (Treatment of endometriosis)
102089-75-8	N-[(1R)-2-[(Methylsulfony l)oxy]-1-phenylethyl]carba mic acid 1,1-dimethylethyl ester
830346-47-9	1-[2-fluoro-6-(trifluorome thyl)benzyl]-6-methylpyri midine-2,4(1H,3H)-dione
830346-48-0	5-Bromo-1-(2-fluoro-6-trif luoromethyl-benzyl)-6-me thyl-1H-pyrimidine-2,4-di one
1150560-54-5	1-[2-fluoro-6-(trifluorome thyl)benzyl]-5-iodo-6-met hylpyrimidine-2,4(1H,3H)- dione
1150560-59-0	5-(2-Fluoro-3-methoxyphe nyl)-1-[[2-fluoro-6-(trifluo romethyl)phenyl]methyl]- 6-methyl-2,4(1H,3H)-pyri midinedione

	Avatrombopag Maleate (Doptelet) CAS:677007-74-8 9 (Treatment of idiopathic thrombocytopenic purpura)
570407-10-2	4-(4-chloro-2-thienyl)-2-T hiazolaMine
570407-42-0	4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine
17766-28-8	1-Cyclohexylpiperazine
41667-95-2	5,6-Dichloronicotinic acid

	Eltrombopag Olamine (Revolade) CAS：496775-62-3 (Treatment of aplastic anemia and thrombocytopenia)
376592-93-7	3'-Amino-2'-Hydroxybi phenyl-3-Carboxylic Acid
376591-95-6	2'-Hydroxy-3'-Nitro-Bip henyl-3-Carboxylic Acid
376591-94-5	2'-Methoxy-3'-Nitro-Bip henyl-3-Carboxylic Acid
18048-64-1	3-Methyl-1-(3,4-dimeth ylphenyl)-2-pyrazolin-5-one
277299-70-4	2-(3,4-Dimethylphenyl)-1,2-dihydro-5-methyl- 3H-pyrazol-3-one
98775-19-0	1-Bromo-2-Methoxy-3- Nitrobenzene
688363-79-3	2-(benzyloxy)-1-bromo-3-nitrobenzene

	Lumateperone Tosylate (ITI-007, ITI-722, Caplyta ) CAS：1187020-80-9 (Treatment of schizophrenia)
2098497-32-4	(4aS,9bR)-Ethyl 6-bromo-5-(2-(methylamino)-2- oxoethyl)-3,4,4a,5-tetrahydro-1 H-pyrido[4,3-b]indole-2(9bH)-c arboxylate
1059630-13-5	(4aS,9bR)-6-bromo-1H,2H,3H,4H,4aH,5H,9bH-pyrido[4,3-b]indo le,(2S)-2-hydroxy-2-phenylaceti c acid;
313368-85-3	(6bR,10aS)-3-Methyl-2,3,6b,7,8,9,10,10a-octahydro-1H-pyrido[3 ',4':4,5]pyrrolo[1,2,3-de]quinoxa line
313544-31-9	Ethyl2-oxo-2,3,9,10-tetrahydro- 1H-pyrido[3',4':4,5]pyrrolo[1,2, 3-de]quinoxaline-8(7H)-carboxy late
	Lenvatinib Mesylate (Lenvima/Kisplyx ) CAS：857890-39-2 (Treatment of differentiated thyroid cancer and unresectable hepatocellular carcinoma)
417721-36-9	4-Chloro-7-Methoxyquinoline-6-Carbo xamide
52671-64-4	4-Amino-3-Chlorophenol Hydrochloride
17609-80-2	4-Amino-3-Chlorophenol

	Upadacitinib CAS 1310726-60-3 (Treatment of rheumatoid arthritis &psoriatic arthritis & ulcerative colitis)
1428243-26-8	(3R,4S)-3-(2-Bromoacetyl)-4-ethyl-1-pyrrolidinecarboxyl ic acid phenylmethyl ester
1869118-25-1	1-[(benzyloxy)carbonyl]-4-e thyl-2,5-dihydro-1H-pyrrole- 3-carboxylic acid
1869118-24-0	Carbamic acid,N-[5-[(4-methylphenyl)sulfo nyl]-5H-pyrrolo[2,3-b]pyrazi n-2-yl]-, ethyl ester
1201187-44-1	N-[5-[(4-Methylphenyl)sulfo nyl]-5H-pyrrolo[2,3-b]pyrazi n-2-yl]carbamic acid 1,1-dimethylethyl ester
1428243-24-6	(3R,4S)-1-((benzyloxy)carbo nyl)-4-ethylpyrrolidine-3-ca rboxylic acid
	Nintedanib Ethanesulfonate (OFEV, Vargatef) CAS 656247-18-6 (Treatment of idiopathic pulmonary fibrosis & non-small cell lung cancer)
262368-30-9	N-(4-Aminophenyl)-N,4-Dimeth yl-1-Piperazineacetamide
14192-26-8	Methyl 2-Oxoindole-6- Carboxylate
1168150-46-6	(3E)-2,3-Dihydro-3-(MethoxyP henylMethylene)-2-Oxo-1H-Ind ole-6-Carboxylic Acid Methyl Ester
1139453-98-7	N-methyl-2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide

	Rimegepant (NURTEC ODT, Vydura) CAS 1289023-67-1 (Treatment of migraines)
39713-40-1	7,8-dihydro-5H-cyclohepta[b] pyridine-5,9(6H)-dione
1190363-45-1	(R)-9-((triisopropylsilyl)oxy)- 6,7,8,9-tetrahydro-5H-cycloh epta[b]pyridin-5-one hydrochloride
1373116-06-3	1-(1-(1H-imidazole-1-carbon yl)piperidin-4-yl)-1H-imidazo [4,5-b]pyridin-2(3H)-one
1190363-46-2	(6S,9R)-6-(2,3-Difluoropheny l)-6,7,8,9-tetrahydro-9-[[tris( 1-methylethyl)silyl]oxy]-5H-c yclohepta[b]pyridin-5-one
781649-84-1	1-piperidin-4-yl-3H-imidazo [4,5-b]pyridin-2-one,dihydro chloride

	Zavegepant (Zavzpret) CAS 1337918-83-8 (For acute treatment of migraine with or without aura in adults)
205058-78-2	3-(piperidin-4-yl)quinolin-2( 1h)-one
890044-58-3	1H-Indazole-5-propanoic acid,α-amino-7-methyl-,met hyl ester, (αR)-
23995-88-2	1-(1-methylpiperidin-4-yl)pi perazine

	Elobixibat (GOOFICE Tablets ) CAS 439087-18-0 (Treat constipation)
100048-86-0	2-(Bromomethyl)-2-butylhexanoic acid
439089-27-7	7-bromo-3,3-dibutyl-8-methoxy-2, 3-dihydrobenzo[b][1,4]thiazepin- 4(5H)-one
439088-74-1	(R)-α-[N-(t-butoxycarbonylmethyl) carbamoyl]benzylamine
	Peramivir (RAPIVAB) CAS 1041434-82-5 (Treatment of influenza virus infections)
168683-02-1	(1S,4R)-methyl 4-(Boc-amino)cyclopent-2-enec arboxylate
316173-28-1	(3aR,4R,6S,6aS)-4-(tert-butoxyc arbonylaMino)-3-(pentan-3-yl)- 4,5,6,6a-tetrahydro-3aH-cyclope nta[d]isoxazole-6-carboxylic acid
229613-93-8	(3aR,4R,6S,6aS)-4-[[(1,1-DiMethylethoxy)carbonyl]aMino]-3-(1- ethylpropyl) 3a,5,6,6a-tetrahydr o-4H-cyclopent[d]isoxazole-6-ca rboxylic Acid Methyl Ester

	Crisaborole (EUCRISA) CAS 906673-24-3 Treatment of atopic dermatitis
2973-80-0	2-Bromo-5-hydroxybenzalde hyde
906673-54-9	4-(4-bromo-3-formylphenox y)benzonitrile
906673-45-8	4-(4-bromo-3-(hydroxymeth yl)phenoxy)benzonitrile

	Elacestrant (Orserdu) CAS 722533-56-4 (Treatment of ER-positive/HER2-negative/ESR1 mutant breast cancer)
32263-70-0	6-(benzyloxy)-3,4-dihydrona phthalen-1(2H)-one
722536-73-4	7-(benzyloxy)-3-bromo-1,2- dihydronaphthalene
2477812-43-2	2-(6-(benzyloxy)-3,4-dihydr onaphthalen-2-yl)-4,4,5,5-tet ramethyl-1,3,2-dioxaborolane
722520-36-7	6-(2-amino-4-methoxypheny l)-5,6,7,8-tetrahydronaphtha len-2-ol
2477812-39-6	(R)-6-(2-amino-4-methoxyp henyl)-5,6,7,8-tetrahydrona phthalen-2-ol
2477812-42-1	N-ethyl-2-(4-formylphenyl)a cetamide
59557-92-5	2-Bromo-5-Methoxyaniline
129968-11-2	2-Bromo-5-methoxyanilineh ydrochloride

	Abrocitinib (Cibinqo) CAS 1622902-68-4 (Treatment of atopic dermatitis)
23761-23-1	3-Oxocyclobutane-1-carboxy licacid
130369-36-7	Benzyl 3-oxocyclobutylcarbamate

	Milvexian CAS 1802425-99-5 (Reduces thrombosis, reduces the risk of ischemic stroke, atrial fibrillation, acute coronary syndrome)
20626-49-7	(R)-2-methylbut-3-enoic acid
1802431-24-8	(5R,9S)-9-amino-21-(difluor omethyl)-5-methyl-21H-3-az a-1(4,2)-pyridina-2(5,4)-pyr azolacyclononaphan-4-one
1802430-55-2	6-(5-chloro-2-(4-chloro-1H- 1,2,3-triazol-1-yl)phenyl)pyr imidin-4-ol

	Vericiguat (Verquvo)CAS 1350653-20-1 (Reduces the risk of heart failure, shock)
1350653-26-7	5-fluoro-1-(2-fluorobenzyl)- 1H-pyrazolo[3,4-b]pyridine- 3-carbonitrile
6017-21-6	Phenylazomalononitrile

	Nemorexant (daridorexant hydrochloride) CAS 1505484-82-1 (Treatment of insomnia in adults)
54413-93-3	2-Iodo-5-methoxybenzoic acid
1293284-55-5	5-methoxy-2-(2H-1,2,3-triaz ol-2-yl)benzoic acid
1788104-76-6	1H-Benzimidazole,6-chloro-7-methyl-2-[(2S)-2- methyl-2-pyrrolidinyl]-, hydrochloride (1:1)
103336-06-7	(S)-1-(tert-butoxycarbonyl)- 2-methylpyrrolidine-2-carbo xylic acid
1508261-86-6	(S)-2-Methylpyrrolidine-2-ca rboxylic acid hydrochloride
673487-36-0	6-Chloro-2,3-diaminotoluene
1087743-89-2	4-Chloro-3-Methylbenzene-1,2-diaMine hydrochloride

	Abemaciclib (Verzenio ) CAS 1231929-97-7 (Treatment of HR-positive, HER2-negative breast cancer/node-positive breast cancer)
1231930-33-8	6-Bromo-4-fluoro-1-isoprop yl-2-methyl-1H-benzo[d]imi dazole
1180132-17-5	5-((4-Ethylpiperazin-1-yl)m ethyl)pyridin-2-amine

	Sparsentan (FILSPARI) CAS 254740-64-2 (Treatment of immunoglobulin A nephropathy)
415697-58-4	(2-(N-(4,5-dimethylisoxazol- 3-yl)-N-(methoxymethyl)sulf amoyl)phenyl)boronic acid
415697-56-2	N-(4,5-dimethylisoxazol-3-yl)-N-(methoxymethyl)-2-(4,4, 5,5-tetramethyl-1,3,2-dioxab orolan-2-yl)benzenesulfona mide
837408-71-6	4-bromo-3-(ethoxymethyl)b enzaldehyde
948349-66-4	4-bromo-3-ethoxymethyl-be nzoic acid ethyl ester
1026913-68-7	N-(4,5-Dimethyl-3-isoxazolyl)-2'-(ethoxymethyl)-4'-form yl-N-(methoxymethyl)[1,1'-b iphenyl]-2-sulfonamide
1098924-76-5	N-(4,5-dimethylisoxazol-3-yl)-2'-(ethoxymethyl)-4'-(hydr oxymethyl)-N-(methoxymet hyl)-[1,1'-biphenyl]-2-sulfon amide

	Remibrutinib CAS 1787294-07-8 (Treatment of chronic urticaria & of multiple sclerosis)
1418128-33-2	5-Fluoro-2-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxabor olan-2-yl)aniline
1787294-51-2	tert-butyl2-(4-amino-6-chloropyrimid in-5-yloxy)ethylmethylcarba mate
1787294-47-6	4-cyclopropyl-2-fluoro-N-(5- fluoro-2-methyl-3-(4,4,5,5-te tramethyl-1,3,2-dioxaborola n-2-yl)phenyl)benzamide

	Peficitinib Hydrobromide (Smyraf Tablets) CAS 1353219-05-2 In the existing treatment methods, rheumatoid arthritis has insufficient effect (including prevention of structural damage to joints)
951625-93-7	Methyl 4-chloro-1H-pyrrolo[2,3-b]p yridine-5-carboxylate
62058-03-1	Trans-4-Amino-1-hydroxy-a damantane

	Ipatacopan Hydrochloride (Fabhalta) CAS 2447007-60-3 (Hemoglobinuria, Paroxysmal)
1387445-50-2	tert-Butyl5-methoxy-7-meth yl-1H-indole-1-carboxylate
1481631-51-9	tert-Butyl4-formyl-5-methoxy-7-meth yl-1H-indole-1-carboxylate
2408761-23-7	tert-butyl 4-formyl-5-hydroxy-7-methy l-1H-indole-1-carboxylate
2408761-22-6	1H-Indole-1-carboxylic acid, 5-hydroxy-7-methyl-,1,1-dimethylethyl ester
1644667-61-7	methyl4-((2S,4S)-4-ethoxypi peridin-2-yl)benzoate
1644667-62-8	Benzoic acid,4-[(2R,4R)-4-ethoxy-2-piperi dinyl]-, methyl ester, rel-

	Elinzanetant CAS 929046-33-3 (Hot Flashes，Hormone receptor positive breast cancer)
929047-29-0	((7S)-octahydropyrazino[2,1-c][1,4]oxazin-7-yl)methanol
212650-43-6	4-Boc-3-morpholinecarboxyl ic Acid
2642577-31-7	6-chloro-4-(4-fluoro-2-meth ylphenyl)pyridin-3-amine
289686-69-7	2-(3,5-bis-trifluoromethylph enyl)-2-methyl-propionyl chloride
825643-73-0	2-(3,5-bis(trifluoromethyl)p henyl)-N-(6-chloro-4-(4-fluo ro-2-methylphenyl)pyridin- 3-yl)-N,2-dimethylpropanam ide

	Pemafibrate (Parmodia) CAS 848259-27-8 (Hyperlipidemias)
907192-60-3	n-butyl (S)-2-trifluoromethanesulfo nyl-oxybutanoate
100841-00-7	3-(4-methoxyphenoxy)prop an-1-amine

	Tenapanor Hydrochloride (Ibsrela) CAS 1234365-97-9 (Hyperphosphatemia & Irritable bowel syndrome with constipation)
1870821-29-6	Isoquinoline,4-(3-bromophenyl)-6,8-dichl oro-1,2,3,4-tetrahydro-2-met hyl-, (4S)-
929-59-9	1,8-Diamino-3,6-dioxaoctane
4538-37-8	1,4-Diisocyanatobutane

	Xanomeline (Karxt) CAS 131986-45-3 (Alzheimer’s disease)
131986-28-2	3-Chloro-4-(pyridin-3-yl)-1, 2,5-thiadiazole

	Roflumilast (Daxas ) CAS 162401-32-3 (Seborrhoeic Dermatitis Atopic Dermatitis Plaque Psoriasis)
151103-08-1	4-Difluoromethoxy-3-hydrox ybenzaldehyde
151103-09-2	4-(DIFLUOROMETHOXY)-3-( CYCLOPROPYLMETHOXY)-B ENZALDEHYDE

	Ritlecitinib Intermediates
1207853-23-3	(2S,5R)-5-amino-2-methylpiperidine-1-carboxylic acid benzyl ester hydrochloride
90213-66-4	2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine

	Enasidenib Intermediates
1446507-40-9	2,4-dichloro-6-(6-(trifluoromethyl)pyridin-2-yl)-1,3,5-triazine
1446507-68-1	4-chloro-6-(6-(trifluoromethyl)pyridin-2-yl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1,3,5-triazin-2-amine

	Prostaglandins Intermediates
32233-40-2	(-)-Corey lactone diol
31752-99-5	(-)-Corey lactone 4-phenylbenzoate alcohol
39746-00-4	(-)-Corey lactone benzoate

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