Synthesis Technology

BerrChem is strong in offering Inermediates, new generics based on GMP quality demands. The company also has a laboratory who can offer fine chemical for R&D department and CRO of pharmaceutical companies.
Chemical Research and Development
BerrChem provides a one-stop, continuous range of problem-solving expertise in chemical synthesis, supported by world-class analytical services. The result is quick, safe and efficient scale-up. Whether it's developing a new process or improving an existing synthetic route, BerrChem can make an impact in the following areas:

• reducing the number of synthetic steps and costs;
• increasing process efficiency, yield and throughput;
• replacing dangerous or environmentally unsuitable chemistries;
• working with complex molecules and multi-step syntheses;
• developing and optimizing existing processes to produce syntheses amenable to commercial manufacturing

Custom Synthesis from Milligram to Kilogram Quantities
If you need milligram quantities of material, think of our company. Our staff has a proven track record of preparing a wide range of compounds on an equally wide range of scales. As your requirements expand, our scientists meet your needs in a timely and cost-effective manner. Since the initial synthesis used to prepare a few milligrams may not be suitable to prepare tens to hundreds to thousands of grams of your target, our staff will adapt and adopt a synthesis that makes the best sense for your needs and expectations.
Scale-Up of Existing Processes
If you already have a demonstrated route and need it reproduced in a timely and efficient manner, our staff will meet or exceed your expectations. Along the way, we will identify and develop steps as appropriate for scale or safety considerations.
Process Research, Development and Optimization
We can develop new and proprietary routes to existing compounds. We will also take an existing synthesis and develop a scalable process using our in-house talent and state-of-the-art technology, including statistical design of experiments, real-time reaction monitoring to generate detailed reaction/impurity profiles, and further process development. Our staff has experience developing and transferring projects from our research laboratories to pilot plant.
Large-Scale Synthesis and Commercial Manufacturing
Once your project reaches this level of maturity, we offer commercial manufacturing facilities at plant of our partner company. Your project will benefit from seamless technology transfer from one stage to the next, as the team that guided your project through development follows the project through commercial manufacturing.

We specialize in the following reactions(sample list only)
Acetylation Acylation Alcoholization
Esterification Enzymatic reactions C-Formylation
C-Alkylation N-Alkylation-acylation N-Formylation
Frieded-Crafts O-Alkylation-acylation Grignard
Amination Hydrochlorination Hydrolysis
Bischler-Napieralski Buchwald Chiral synthesis
Chlorination Catalytic hydrogenation Chlorosulfonation
Condensation Cyclation Cryogenic reactions (until -90C)
Methylation Oxidation Reduction
Suzuki Schotten-Baumann Sulfonation
De-alkylation De-carboxilation De-hydration
De-tosylation N-Tosylation O-Tosylation
Phosgenation Enantioselective catalysis Enantioselective separation/resolution

Boc-4-Amino-D-phenylalanine 4-Amino-3-phenylbutyric acid hydrochloride Equol Troxerutin 5-ETHYL-2'-DEOXYURIDINE Berberine 7-HYDROXYISOFLAVONE Flumethasone Acetyl cedrene PROPOXYPHENE HYDROCHLORIDE 2-Methyl-3-nitrobenzyl alcohol Z-ARG(Z)2-OH Diethyl 2-ethyl-2-phenylmalonate SANTONIN 7-(2-HYDROXYETHYL)THEOPHYLLINE 3-(Chloromethyl)benzoic acid FLAVOXATE (6R-(6alpha,7))-((Amino-1,4-cyclohexadien-1-ylacetyl)amino)-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid RESCINNAMINE N-Benzyl-9-(tetrahydro-2H-pyran-2-yl)adenine 2-Chloro-1,4-naphthoquinone BOC-HIS(Z)-OH 4-Methoxy-2,5-dimethyl-3(2H)-furanone L-Phenylalaninamide hydrochloride KAINIC ACID HARMINE HYDROCHLORIDE HYDRATE Piracetam 4-tert-Butyl-2,6-dinitrophenol DIHEXYVERINE, HYDROCHLORIDE Vinflunine Tilmicosin phosphate DOMOIC ACID Desogestrel Ethyl 2,4-dimethyl-5-(ethoxycarbonyl)-3-pyrrolepropionate 3-(2-FURANYLMETHYL)-3,7-DIHYDRO-1,8-DIMETHYL-1H-PURINE-2,6-DIONE Magnesium salicylate 2,3,6-TRIFLUOROPHENOL 16-beta Methyl Epoxide Cilostazol Triptorelin 2,4-Difluorobenzotrifluoride Sodium 2-diazo-1-naphthol-5-sulfonate BUDIPINE 1-Fluoro-2-(2-nitrovinyl)benzene 2,5-Dihydrofuran Dikegulac sodium OXANTEL Flunarizine dihydrochloride Valaciclovir N-(2,6-DIISOPROPYLPHENYL-CARBAMOYLMETHYL)IMINODIACETIC ACID 3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene DIOSMETIN HEXYL FORMATE Ginkgolide A CAERULEIN 3-(1-NAPHTHYL)-D-ALANINE HYDROCHLORIDE 2-CHLORO-9-(3-DIMETHYLAMINO-PROPYL)-9-HYDROXY THIOANTHRACENE 5-Methyl-1H-indazole-3-carboxylic acid Nabumetone PROMAZINE DL-Ephedrine hydrochloride SEGLITIDE Roquinimex (+)-PERILLAALDEHYDE DEANOL ACEGLUMATE Nitrendipine Belarizine Hydrocortisone sodium phosphate BENORILATE 7-[(2-Hydroxy-2-phenylacetyl)amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Clindamycin hydrochloride Febuprol Armillarisin A Enoxacin TALAMPICILLIN DIPERODON HYDROCHLORIDE

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